HSV-2 infection not only complicates the sex lives of couples, it also increases a person’s susceptibility to HIV, the virus that causes AIDS. Less than 1% of teens in the United States are infected, but that increases to 21% of Americans in their 40s, according to the Centers for Disease Control and Prevention. The prevalence of this chronic disease increases with age. According to the World Health Organization, two-thirds of the world population under the age of 50 carry herpes simplex virus type 1, or HSV-1, which primarily causes cold sores, while 491 million people aged 15-49 are infected with closely related HSV-2, which is the cause of sexually transmitted genital herpes.Īlthough the antiviral drug acyclovir can knock down an outbreak of HSV-2, the virus lingers for a lifetime within infected nerve cells and may reactivate, causing recurrent bouts of painful sores, on average, two to seven times per year. Herpes simplex viruses afflict billions of human beings around the globe. Jerome estimates that will be at least three years away. It will still take a long time before these experiments lead to the first human trials of gene therapy to cure herpes. “I hope that this study changes the dialogue around herpes research and opens up the idea that we can start thinking about cure, rather than just control of the virus,” Jerome said. Whereas most research on herpes has focused on suppressing the recurrence of painful symptoms, the Fred Hutch gene therapy work addresses the root cause of reactivation: the presence of latent virus in infected nerve cells. Much of the team’s meticulous work of the past five years has involved finding better ways to target infected clusters of nerve cells and to thwart the virus’s ability to quickly repair the cuts to its genes. The hidden herpes viruses are disabled by an injection that tracks down infected nerve cells and induces them to make special gene-cutting enzymes, which work like a molecular scissors, to slash viral genes in specific places. “It is a completely different approach to herpes therapy than anybody’s ever had before.” “This is the first time that anybody has been able to go in and actually eliminate most of herpes in a body,” said Jerome, who is also spearheading research at Fred Hutch and the University of Washington on COVID-19. 18, the team led by Jerome and Aubert published a paper in Nature Communications showing that, through a series of incremental improvements on their original method, they had destroyed up to 95% of herpes virus lurking in certain nerve clusters of mice. Viruses, Vaccines and Infectious Diseases.Institutional Partners & Collaborations.Vaccine and Infectious Disease Division.They do note though that this does not result in immunity to herpes, and people can still be reinfected. Bloomberg and CBS wrote articles about it that gives me the hint that it might actually be real. Normally I'm skeptical of all of these "cures", but I'm finding several articles about how the tests they conducted did actually result in some, not all, of the participants going from testing positive to negative after about a ~90 day treatment. What exactly they all are, I'm not sure yet, I have to read more into them. These 5CC are effective inhibitors of herpes viral DNA synthesis and interferon (IFN)-induced cellular antiviral response and were found to neutralize antiviral reproduction by blocking cell-to-cell infection.īasically, a combination of 5 different pills. The treatment consisted of five immunotherapeutic core compounds (5CC) comprising of Rhodiola, Tribulus, Astragalus, Lysine and a proprietary Amino Acid Formula. I just stumbled upon these articles about Synergy Pharmaceuticals and their apparent natural cure for herpes using: I tried crossposting this from r/herpes, but it wasn't working, but anyways:
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